How to Take ZYTIGA®| ZYTIGA® (abiraterone acetate)

Taking Your ZYTIGA^® Tablets

ZYTIGA^® (abiraterone acetate) is an oral, once-daily medication that you can take at home. ZYTIGA^® is a prescription medicine that is used along with prednisone.

It’s important to take ZYTIGA^® + prednisone exactly as your healthcare provider tells you to and to stay on the treatment schedule recommended by your doctor to give ZYTIGA^® the best opportunity to work.

Follow Your Doctor’s Instructions

Take your prescribed dose of ZYTIGA^® one time a day. Your healthcare provider may change your dose, if needed.
Also, take your prednisone exactly how your healthcare provider tells you to.

It’s important to take your prescribed dose of ZYTIGA^® tablets once daily
Swallow ZYTIGA^® tablets whole. Do not crush or chew tablets
Take ZYTIGA^® tablets with water

Take ZYTIGA^® on an empty stomach, at least 1 hour before or at least 2 hours after a meal
Do not take ZYTIGA^® with food. Taking ZYTIGA^® with food may cause more of the medicine to be absorbed by the body than is needed and this may cause side effects

While taking ZYTIGA^®, you will also take prednisone
Take your prednisone exactly how your doctor tells you. Do not change or stop taking your prescribed dose of ZYTIGA^® or prednisone without talking to your doctor first

Taking Other Medications With ZYTIGA^®

Tell your healthcare provider and your pharmacist about all the medicines you take or treatments you receive. It’s important to share information about any other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements you are taking.

ZYTIGA^® can interact with many other medications.

You should not start or stop any medicine before you talk with the doctor who prescribed ZYTIGA^®.

What If You Miss a Dose

If you ever miss a dose of ZYTIGA^® or prednisone, take your prescribed dose the following day.

If you miss more than 1 dose of ZYTIGA^® or prednisone, tell your doctor right away.

Tips to Help You Stay on Your Treatment Schedule

It’s helpful to develop a system or plan to help you take your ZYTIGA^® every single day with prednisone and plan ahead for refills.
Be sure to plan ahead if you’re going on a trip and will need a refill of your medicine. It’s also a good idea to ask your friends or loved ones to help you keep track of your medications.
Contact Janssen CarePath at 855-ZYTIGA-1 (855-998-4421) or create a Janssen CarePath account at MyJanssenCarePath.com to set up personalized prescription refill reminders. Talk to your doctor about developing a medication schedule that's right for you.

Find Additional Helpful Tips & Resources from Janssen

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Before taking ZYTIGA^®, tell your healthcare provider about all of your medical conditions, including if you:

Have heart problems
Have liver problems
Have a history of adrenal problems
Have a history of pituitary problems
Are receiving any other treatment for prostate cancer
Are pregnant or plan to become pregnant. ZYTIGA^® can cause harm to your unborn baby and loss of pregnancy (miscarriage). Females who are or may become pregnant should not handle ZYTIGA^® uncoated tablets or other ZYTIGA^® tablets if broken, crushed, or damaged without protection, such as gloves
Have a partner who is pregnant or may become pregnant
- Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with ZYTIGA^® and for 3 weeks after the last dose of ZYTIGA^®
Are breastfeeding or plan to breastfeed. It is not known if ZYTIGA^® passes into your breast milk

Tell your healthcare provider about all the medicines you take or treatments you receive including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZYTIGA^® can interact with many other medicines.

How should I take ZYTIGA^®?

Take ZYTIGA^® and prednisone exactly as your healthcare provider tells you
Take your prescribed dose of ZYTIGA^® one time a day. Your healthcare provider may change your dose if needed
Do not change or stop taking your prescribed dose of ZYTIGA^® or prednisone without talking to your healthcare provider first
Take ZYTIGA^® on an empty stomach, at least 1 hour before or at least 2 hours after a meal. Do not take ZYTIGA^® with food. Taking ZYTIGA^® with food may cause more of the medicine to be absorbed by the body than is needed and this may cause side effects
Swallow ZYTIGA^® tablets whole. Do not crush or chew tablets
Take ZYTIGA^® tablets with water
If you miss a dose of ZYTIGA^® or prednisone, take your prescribed dose the following day. If you miss more than 1 dose, tell your healthcare provider right away
Your healthcare provider will do blood tests to check for side effects

What are the possible side effects of ZYTIGA^®?

ZYTIGA^® may cause serious side effects including:

High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats can happen during treatment with ZYTIGA^®. This can be life-threatening. To decrease the chance of this happening, you must take prednisone with ZYTIGA^® exactly as your healthcare provider tells you. Your healthcare provider will check your blood pressure, do blood tests to check your potassium levels, and check for any signs and symptoms of fluid retention every month during treatment with ZYTIGA^®
Tell your healthcare provider if you get any of the following symptoms:
- Dizziness
- Fast or irregular heartbeats
- Feel faint or lightheaded
- Headache
- Confusion
- Muscle weakness
- Pain in your legs
- Swelling in your legs or feet

Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress
Liver problems. You may develop changes in liver function blood tests. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA^® and during treatment with ZYTIGA^®. Liver failure may occur, which can lead to death. Tell your healthcare provider if you notice any of the following changes:
- Yellowing of the skin or eyes
- Darkening of the urine
- Severe nausea or vomiting
Increased risk of bone fracture and death when ZYTIGA^® and prednisone or prednisolone is used in combination with a type of radiation called radium Ra 223 dichloride. Tell your healthcare provider about any other treatments you are taking for prostate cancer
The most common side effects of ZYTIGA^® include:
- Feeling very tired
- Joint pain
- High blood pressure
- Nausea
- Swelling in your legs or feet
- Low blood potassium levels
- Hot flushes
- Diarrhea
- Vomiting
- Infected nose, sinuses, or throat
- Cough
- Headache
- Low red blood cells (anemia)
- High blood cholesterol and triglycerides
- High blood sugar levels
- Certain other abnormal blood tests

ZYTIGA^® may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA^®.

ZYTIGA^® can interact with other medicines.

You should not start or stop any medicine before you talk with the healthcare provider who prescribed ZYTIGA^®.

Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.

Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).

Please see the full Prescribing Information and Patient Information for ZYTIGA^® and discuss any questions you have with your doctor.

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How to Take ZYTIGA®

Taking Your ZYTIGA® Tablets