ZYTIGA^® may cause serious side effects including:

• High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats can happen during treatment with ZYTIGA^®.
  Tell your healthcare provider if you get any of the following symptoms:
  • Dizziness
  • Fast or irregular heartbeats
  • Feel faint or lightheaded
  • Headache
  • Confusion
  • Muscle weakness
  • Pain in your legs
  • Swelling in your legs or feet
• Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress
• Liver problems. You may develop changes in liver function blood tests. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA^® and during treatment with ZYTIGA^®. Liver failure may occur, which can lead to death. Tell your healthcare provider if you notice any of the following changes:
  • Yellowing of the skin or eyes
  • Darkening of the urine
  • Severe nausea or vomiting

• The most common side effects of ZYTIGA^® include:
  • Feeling very tired
  • Joint pain
  • High blood pressure
  • Nausea
  • Swelling in your legs or feet
  • Low blood potassium levels
  • Hot flushes
  • Diarrhea
  • Vomiting
  • Infected nose, sinuses, or throat
  • Cough
  • Headache
  • Low red blood cells (anemia)
  • High blood cholesterol and triglycerides
  • High blood sugar levels
  • Certain other abnormal blood tests

ZYTIGA^® may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.