ZYTIGA® Inhibits Androgen Production at 3 Sources — Including the Tumor Itself
ZYTIGA® works by interrupting the androgen-making process at an important step, thereby reducing the amount of androgen being made.
The Role of Androgen in Metastatic Castration-Resistant Prostate Cancer
You may be aware that the male body produces hormones called androgens. If you’ve been on Androgen Deprivation Therapy, you are most likely familiar with the role and significance of androgen in prostate cancer.
Androgens are primarily made in the testes and the adrenal glands. However, in metastatic castration-resistant prostate cancer (prostate cancer that is resistant to medical or surgical treatments that lower testosterone and has spread to other parts of the body) the tumor itself can be a source for androgen production.
Reducing the production of androgen is key to helping you and your doctor manage your illness, because even a small amount of androgen may activate the tumor.
ZYTIGA® may cause serious side effects, including:
High blood pressure (hypertension), low blood potassium (hypokalemia), and fluid retention (edema).
Tell your healthcare provider if you get any of the following symptoms:
Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress.
Liver problems. You may develop changes in liver function blood test. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA® and during treatment with ZYTIGA®.
The most common side effects of ZYTIGA® include:
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA®. FOR MORE INFORMATION, ASK YOUR HEALTHCARE PROVIDER OR PHARMACIST.
Please see additional Important Safety Information below.