ZYTIGA® Inhibits Androgen Production at 3 Sources — Including the Tumor Itself

ZYTIGA® works by interrupting the androgen-making process at an important step, thereby reducing the amount of androgen being made.

The Role of Androgen in Metastatic Castration-Resistant Prostate Cancer

You may be aware that the male body produces hormones called androgens. If you’ve been on Androgen Deprivation Therapy, you are most likely familiar with the role and significance of androgen in prostate cancer.

Androgens are primarily made in the testes and the adrenal glands. However, in metastatic castration-resistant prostate cancer (prostate cancer that is resistant to medical or surgical treatments that lower testosterone and has spread to other parts of the body) the tumor itself can be a source for androgen production.

Reducing the production of androgen is key to helping you and your doctor manage your illness, because even a small amount of androgen may activate the tumor.

ZYTIGA® may cause serious side effects, including:

High blood pressure (hypertension), low blood potassium (hypokalemia), and fluid retention (edema).

Tell your healthcare provider if you get any of the following symptoms:

  • Dizziness
  • Fast heartbeats
  • Feel faint or lightheaded
  • Headache
  • Confusion
  • Muscle weakness
  • Pain in your legs
  • Swelling in your legs or feet

Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress.

Liver problems. You may develop changes in liver function blood test. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA® and during treatment with ZYTIGA®.

The most common side effects of ZYTIGA® include:

  • Weakness
  • Joint swelling or pain
  • Swelling in your legs or feet
  • Hot flushes
  • Diarrhea
  • Vomiting
  • Cough
  • High blood pressure
  • Shortness of breath
  • Urinary tract infection
  • Bruising
  • Low red blood cells (anemia) and low blood potassium levels
  • High blood sugar levels, high blood cholesterol and triglycerides
  • Certain other abnormal blood tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA®. FOR MORE INFORMATION, ASK YOUR HEALTHCARE PROVIDER OR PHARMACIST.

Please see additional Important Safety Information below.

What is ZYTIGA®?

ZYTIGA® (abiraterone acetate) is a prescription medicine that is used along with prednisone. ZYTIGA® is used to treat men with castration-resistant prostate cancer (prostate cancer that is resistant to medical or surgical treatments that lower testosterone) that has spread to other parts of the body.

IMPORTANT SAFETY INFORMATION

Who should not take ZYTIGA®?

Do not take ZYTIGA® if you are pregnant or may become pregnant. ZYTIGA® may harm your unborn baby. Women who are pregnant or who may become pregnant should not touch ZYTIGA® without protection, such as gloves.

ZYTIGA® is not for use in women or children. Keep ZYTIGA® and all medicines out of the reach of children.

Before you take ZYTIGA®, tell your healthcare provider if you:

If you are taking ZYTIGA®:

ZYTIGA® may cause serious side effects including:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA®.
FOR MORE INFORMATION, ASK YOUR HEALTHCARE PROVIDER OR PHARMACIST.

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

ZYTIGA® can interact with other medicines.

You should not start or stop any medicine before you talk with the healthcare provider that prescribed ZYTIGA®.

Know the medicines you take. Keep a list of them with you to show to your healthcare provider and pharmacist when you get a new medicine.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).

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